{"nmadb.ID":501330,"PMID":"15147585","First.Author":"Mason","Year":"2004","Journal.Name":"BMC Fam Pract","Title":"Topical NSAIDs for acute pain: a meta-analysis.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Additional File 4 & 5","Comment":"There is great variability in 'injuries' level (circa 18 levels across 35 studies). This characteristic will not be extracted."}
{"nmadb.ID":479574,"PMID":"15820294","First.Author":"Biondi-Zoccai","Year":"2005","Journal.Name":"Int J Cardiol","Title":"Adjusted indirect comparison of intracoronary drug-eluting stents: evidence from a metaanalysis of randomized bare-metal-stent-controlled trials","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Table 1 & 2","Comment":"Risk of bias is not reported."}
{"nmadb.ID":501268,"PMID":"15968013","First.Author":"Gafter-Gvili","Year":"2005","Journal.Name":"Ann Intern Med","Title":"Meta-Analysis: Antibiotic Prophylaxis Reduces Mortality in Neutropenic Patients.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Appendix Tables 1 &2","Comment":"In some trials, more than one interventions are used but the review does not specify which intervention was used in the analysis. Moreover, some trials report the dose in gr and others in mg/kg. Due to the uncertainty in intervention analysed and the inconsistency in the reported dose, dose will not be extracted."}
{"nmadb.ID":481193,"PMID":"16354303","First.Author":"Moore","Year":"2005","Journal.Name":"BMC Urol","Title":"Indirect comparison of interventions using published randomised trials: systematic review of PDE-5 inhibitors for erectile dysfunction","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Additional file 1 & 2","Comment":"NA"}
{"nmadb.ID":479688,"PMID":"16442888","First.Author":"Zhou","Year":"2005","Journal.Name":"Am Heart J","Title":"Are statins created equal? Evidence from randomized trials of pravastatin, simvastatin, and atorvastatin for cardiovascular disease prevention","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Risk of bias is not reported."}
{"nmadb.ID":501211,"PMID":"16239897","First.Author":"Berner","Year":"2006","Journal.Name":"Int J Impot Res","Title":"Efficacy of PDE-5-inhibitors for erectile dysfunction. A comparative meta-analysis of fixed-dose regimen randomized controlled trials administeringthe International Index of Erectile Function in broad-spectrum populations.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"NA"}
{"nmadb.ID":501354,"PMID":"16670414","First.Author":"Nelson","Year":"2006","Journal.Name":"JAMA","Title":"Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 to 5","Comment":"The comparisons differ concerning some characteristics (e.g., use of tamoxifen is only reported by trials investigating SSRIs/SNRIs). Hence, only characteristics reported for all comparisons were considered for extraction."}
{"nmadb.ID":501300,"PMID":"16684428","First.Author":"Jansen","Year":"2006","Journal.Name":"Curr Med Res Opin","Title":"Self-monitoring of glucose in type 2 diabetes mellitus: a Bayesian meta-analysis of direct and indirect comparisons.","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 1 & 2","Comment":"The description of 'inclusion criteria' and 'interventions' is textual and creating unique characteristics is difficult due to inconsistent reporting across the trials (risk of severe missingness). Only baseline HbA1c, follow-up and internal validity measures are extractable."}
{"nmadb.ID":501236,"PMID":"16801509","First.Author":"Cooper","Year":"2006","Journal.Name":"Arch Intern Med","Title":"Mixed comparison of stroke prevention treatments in individuals with noNRheumatic atrial fibrillation.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Risk of bias domains are not reported."}
{"nmadb.ID":501217,"PMID":"17018227","First.Author":"Brown","Year":"2006","Journal.Name":"Health Technol Assess","Title":"A comparison of the cost-effectiveness of five strategies for the prevention of non-steroidal anti-inflammatory drug-induced gastrointestinal toxicity: a systematic review with economic modelling.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix Table 6","Comment":"NA"}
{"nmadb.ID":480655,"PMID":"16951908","First.Author":"Vestergaard","Year":"2007","Journal.Name":"Osteoporos Int","Title":"Effects of parathyroid hormone alone or in combination with antiresorptive therapy on bone mineral density and fracture risk - a meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"NA"}
{"nmadb.ID":501355,"PMID":"17478472","First.Author":"Nixon","Year":"2007","Journal.Name":"Rheumatology","Title":"The efficacy of inhibiting tumour necrosis factor a and interleUnited Kingdomin 1 in patients with rheumatoid arthritis: a meta-analysis and adjusted indirect comparisons","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"For trials with multiple doses on a treatment, the clinical characteristics were extracted per dose. Risk of bias is not reported."}
{"nmadb.ID":501336,"PMID":"17651658","First.Author":"McLeod","Year":"2007","Journal.Name":"Health Technol Assess","Title":"Adalimumab, etanercept and infliximab for the treatment of ankylosing spondylitis: a systematic review and economic evaluation.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 2 to 4","Comment":"NA"}
{"nmadb.ID":501395,"PMID":"17903393","First.Author":"Soares-Weiser","Year":"2007","Journal.Name":"Health Technol Assess","Title":"A systematic review and economic model of the clinical effectiveness and cost-effectiveness of interventions for preventing relapse in people with bipolar disorder.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Tables 1 & 2, Appendix Tables 5","Comment":"NA"}
{"nmadb.ID":501309,"PMID":"17932160","First.Author":"Lam","Year":"2007","Journal.Name":"BMJ","Title":"Combined resynchronisation and implantable defibrillator therapy in left ventricular dysfunction: Bayesian network meta-analysis of randomised controlled trials.","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"NA"}
{"nmadb.ID":481908,"PMID":"18482285","First.Author":"Chou","Year":"2008","Journal.Name":"J Viral Hepat","Title":"Pegylated interferons for chronic hepatitis C virus infection: an indirect analysis of randomized trials","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Table 5","Comment":"NA"}
{"nmadb.ID":501192,"PMID":"18681088","First.Author":"Abdullah","Year":"2008","Journal.Name":"Ann Allergy Asthma Immunol","Title":"Relative oral corticosteroid-sparing effect of 7 inhaled corticosteroids in chronic asthma: a meta-analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"NA"}
{"nmadb.ID":480679,"PMID":"18686744","First.Author":"Hansen","Year":"2008","Journal.Name":"Clin Interv Aging","Title":"Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Sample size is not reported in nmadb or the article."}
{"nmadb.ID":501345,"PMID":"19022156","First.Author":"Mills","Year":"2008","Journal.Name":"J Am Coll Cardiol","Title":"Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"NA"}
{"nmadb.ID":501370,"PMID":"15266524","First.Author":"Playford","Year":"2009","Journal.Name":"Cochrane Database Syst Rev","Title":"Antifungal agents for preventing fungal infections in solid organ transplant recipients.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies & Appendix Tables 2 to 3","Comment":"NA"}
{"nmadb.ID":501277,"PMID":"15495054","First.Author":"Goudswaard","Year":"2009","Journal.Name":"Cochrane Database Syst Rev","Title":"Insulin monotherapy versus combinations of insulin with oral hypoglycaemic agents in patients with type 2 diabetes mellitus.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies","Comment":"NA"}
{"nmadb.ID":501324,"PMID":"16235370","First.Author":"Macfayden","Year":"2009","Journal.Name":"Cochrane Database Syst Rev","Title":"Topical antibiotics without steroids for chronically discharging ears with underlying eardrum perforations.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies & Appendix Table 1","Comment":"Only the methodological characteristics are extractable (sequence generation, allocation concealment, baseline balance, blinding and follow-up)."}
{"nmadb.ID":501372,"PMID":"17253468","First.Author":"Pollock","Year":"2009","Journal.Name":"Cochrane Database Syst Rev","Title":"Physiotherapy treatment approaches for the recovery of postural control and lower limb function following stroke.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix Tables 2, 3 and 4","Comment":"NA"}
{"nmadb.ID":501374,"PMID":"19144173","First.Author":"Puhan","Year":"2009","Journal.Name":"BMC Med","Title":"Inhaled drugs to reduce exacerbations in patients with chronic obstructive pulmonary disease: a network meta-analysis.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Appendix 3","Comment":"NA"}
{"nmadb.ID":501407,"PMID":"19286090","First.Author":"Trikalinos","Year":"2009","Journal.Name":"Lancet","Title":"Percutaneous coronary interventions for non-acute coronary artery disease: a quantitative 20-year synopsis and a network meta-analysis.","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix Table 1 to 4","Comment":"There are duplicated studies that have used the same patients as revealed by the same sample size per arm. Risk of bias domains are not found."}
{"nmadb.ID":482362,"PMID":"19357145","First.Author":"Strassman","Year":"2009","Journal.Name":"Eur Respir J","Title":"Smoking cessation interventions in COPD: a network meta-analysis of randomised trials","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 1 & 2","Comment":"Table 1 contains textual description of population and intervention, except for sample size, % male and mean age. Table 2 contains the risk of bias domains."}
{"nmadb.ID":476033,"PMID":"19530978","First.Author":"Jansen","Year":"2009","Journal.Name":"Curr Med Res Opin","Title":"Prevention of vertebral fractures in osteoporosis: mixed treatment comparison of bisphosphonate therapies","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Risk of bias domains are not found."}
{"nmadb.ID":501197,"PMID":"19604457","First.Author":"Ara","Year":"2009","Journal.Name":"Health Technol Assess","Title":"Early high-dose lipid-lowering therapy to avoid cardiac events: a systematic review and economic evaluation.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 2 to 4","Comment":"NA"}
{"nmadb.ID":501201,"PMID":"19637942","First.Author":"Baker","Year":"2009","Journal.Name":"Pharmacotherapy","Title":"Pharmacologic treatments for chronic obstructive pulmonary disease: a mixed-treatment comparison meta-analysis.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"The categorisation of the definition of COPD exacerbation should be considered with great caution."}
{"nmadb.ID":501207,"PMID":"19657180","First.Author":"Bansback","Year":"2009","Journal.Name":"Dermatology","Title":"Efficacy of systemic treatments for moderate to severe plaque psoriasis: systematic review and meta-analysis.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"NA"}
{"nmadb.ID":501348,"PMID":"19761618","First.Author":"Mills","Year":"2009","Journal.Name":"Harm Reduct J","Title":"Efficacy of pharmacotherapies for short-term smoking abstinance: a systematic review and meta-analysis.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix 1","Comment":"Dosage has a different measurement scale in some trials, making its extraction not straightforward. There is no information on the risk of bias domains in the main manuscript or supplementary material. It was challenging to spot the trials in the supplementary material (years and names did not agree 100% with those in nmadb)."}
{"nmadb.ID":479808,"PMID":"19821440","First.Author":"Singh","Year":"2009","Journal.Name":"Cochrane Database Syst Rev","Title":"Biologics for rheumatoid arthritis: an overview of Cochrane reviews","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Additional Table 1","Comment":"Risk of bias domains not found."}
{"nmadb.ID":481216,"PMID":"20223500","First.Author":"Bergman","Year":"2010","Journal.Name":"Semin Arthritis Rheum","Title":"Indirect Comparison of Tocilizumab and Other Biologic Agents in Patients with Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic Drugs","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix Table 1","Comment":"Risk of bias domains not found"}
{"nmadb.ID":501366,"PMID":"20388897","First.Author":"Phung","Year":"2010","Journal.Name":"JAMA","Title":"Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"eTable 1","Comment":"NA"}
{"nmadb.ID":501430,"PMID":"20600036","First.Author":"Woo","Year":"2010","Journal.Name":"Gastroenterology","Title":"Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and Bayesian meta-analyses.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1 & Figure 3","Comment":"Only information on the risk of bias domains, sample size and treatment duration were extractable."}
{"nmadb.ID":480851,"PMID":"20614454","First.Author":"Stowe","Year":"2010","Journal.Name":"Cochrane Database Syst Rev","Title":"Evaluation of the efficacy and safety of adjuvant treatment to levodopa therapy in Parkinson´ s disease patients with motor complications","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies","Comment":"NA"}
{"nmadb.ID":501424,"PMID":"20638155","First.Author":"Wang","Year":"2010","Journal.Name":"J Hosp Infect","Title":"Effectiveness of different central venous catheters for catheter-related infections: a network meta-analysis.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"NA"}
{"nmadb.ID":501340,"PMID":"20713583","First.Author":"Middleton","Year":"2010","Journal.Name":"BMJ","Title":"Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding: systematic review andmeta-analysis of data from individual patients","Outcome.Type":"Subjective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix Tables 2 (for sample size) & 3","Comment":"Appendix 3 has sufficient extractable characteristics. Textual description in Appendix 1 that cannot be quantified."}
{"nmadb.ID":501299,"PMID":"20738930","First.Author":"Imamura","Year":"2010","Journal.Name":"Health Technol Assess","Title":"Systematic review and economic modelling of the effectiveness and cost-effectiveness of non-surgical treatments for women with stress urinary incontinence.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 14 (Appendix Table 10) & Appendix 9 (RoB)","Comment":"NA"}
{"nmadb.ID":481571,"PMID":"20825624","First.Author":"Dakin","Year":"2010","Journal.Name":"Value Health","Title":"Mixed Treatment Comparison Meta-Analysis Evaluating the Relative Efficacy of Nucleos(t)ides for Treatment of Nucleos(t)ide-Naive Patients with Chronic Hepatitis B","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 2","Comment":"NA"}
{"nmadb.ID":501302,"PMID":"20828791","First.Author":"Jansen","Year":"2010","Journal.Name":"Semin Arthritis Rheum","Title":"The Effcacy of Bisphosphonates in the Prevention of Vertebral, Hip, and Nonvertebral-Nonhip Fractures in Osteoporosis: A Network Meta-Analysis.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Risk of bias domains were not found."}
{"nmadb.ID":501423,"PMID":"20847017","First.Author":"Wandel","Year":"2010","Journal.Name":"BMJ","Title":"Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1 & 2 (for sample size)","Comment":"NA"}
{"nmadb.ID":501414,"PMID":"19965836","First.Author":"Van den Bruel","Year":"2011","Journal.Name":"Br J Ophthalmol","Title":"The protective effect of ophthalmic viscoelastic devices on endothelial cell loss during cataract surgery: a meta-analysis using mixed treatment comparisons","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 2 & 3","Comment":"NA"}
{"nmadb.ID":501408,"PMID":"20584209","First.Author":"Tropeano","Year":"2011","Journal.Name":"Fundam Clin Pharmacol","Title":"Do all antihypertensive drugs improve carotid intima-media thickness? A network meta-analysis of randomized controlled trials.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Mean age is missing in most trials, and was not extracted."}
{"nmadb.ID":501346,"PMID":"20934984","First.Author":"Mills","Year":"2011","Journal.Name":"QJM","Title":"Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Patient status has too many categories to be extracted without expert opinion."}
{"nmadb.ID":501206,"PMID":"21123111","First.Author":"Bangalore","Year":"2011","Journal.Name":"Lancet Oncol","Title":"Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324,168 participants from randomised trials.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Appendix Table B","Comment":"The characteristic 'Cohort' (Table 1) contains several categories that cannot be further categorised without expert opinion. This is a limitation. Table 1 reports the Risk of bias but it does not clarify for which domains; hence, RoB could not be extracted."}
{"nmadb.ID":501215,"PMID":"21142838","First.Author":"Bottomley","Year":"2011","Journal.Name":"Curr Med Res Opin","Title":"The effectiveness of two-compound formulation calcipotriol and betamethasone dipropionate gel in the treatment of moderately severe scalp psoriasis: a systematic review of direct and indirect evidence.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 2","Comment":"NA"}
{"nmadb.ID":480629,"PMID":"21182357","First.Author":"Devine","Year":"2011","Journal.Name":"Pharmacotherapy","Title":"Effectiveness of Biologic Therapies for Rheumatoid Arthritis: An Indirect Comparisons Approach","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 2","Comment":"NA"}
{"nmadb.ID":501381,"PMID":"21199320","First.Author":"Roskell (1)","Year":"2011","Journal.Name":"Pain Pract","Title":"A meta-analysis of pain response in the treatment of fibromyalgia.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 2","Comment":"No supplementary material was. No information on the risk of bias domains"}
{"nmadb.ID":501195,"PMID":"21205969","First.Author":"Anothaisintawee","Year":"2011","Journal.Name":"JAMA","Title":"Management of Chronic Prostatitis/Chronic Pelvic Pain Syndrome A Systematic Review and Network Meta-analysis.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Risk of bias domains are not found."}
{"nmadb.ID":501313,"PMID":"21239748","First.Author":"Launois","Year":"2011","Journal.Name":"J Rheumatol","Title":"Comparison of Certolizumab Pegol with Other Anticytokine Agents for Treatment of Rheumatoid Arthritis: A Multiple-treatment Bayesian Metaanalysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"NA"}
{"nmadb.ID":501429,"PMID":"21248357","First.Author":"Wong","Year":"2011","Journal.Name":"J Dent Res","Title":"Cochrane Reviews on the Benefits/Risks of Fluoride Toothpastes","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix 2","Comment":"NA"}
{"nmadb.ID":501365,"PMID":"21349929","First.Author":"Phung","Year":"2011","Journal.Name":"Chest","Title":"Dosing frequency of unfractionated heparin thromboprophylaxis: A meta-analysis.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Indication for prophylaxis' has been categorised into 3 distinct groups and this should be considered with great caution."}
{"nmadb.ID":482001,"PMID":"21406529","First.Author":"Jalota","Year":"2011","Journal.Name":"BMJ","Title":"Prevention of pain on injection of propofol: systematic review and meta-analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Web Table 1","Comment":"The extracted sample size is not reliable for multi-arm trials: Web Table 1 does not give this information per arm; hence, for each comparison the sample size as reported for the whole trial was used (this is a limitation). Some trials are duplicated."}
{"nmadb.ID":501367,"PMID":"21429006","First.Author":"Phung","Year":"2011","Journal.Name":"Diabet Med","Title":"Oral anti-diabetic drugs for the prevention of Type 2 diabetes.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Concurrent medication, inclusion parameters, and diabetes development definition are a mixture of text and numbers, and will not be extracted."}
{"nmadb.ID":501358,"PMID":"21438991","First.Author":"Padwal","Year":"2011","Journal.Name":"Obes Rev","Title":"Bariatric surgery: a systematic review and network meta-analysis of randomized trials","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"Comment in nmadb: \"This data was sent to us from the author, it is based on a 1-year update of the original NMA that includes 5 additional studies and 1 additional treatment. The code the author sent us did not contain any identifying information for the trials and thus it is impossible to determine which were originally included in the NMA and which are from the update\". All studies included in Tables 1 and 2 of the manuscript were considered and the raw data of nmadb were not considered."}
{"nmadb.ID":501239,"PMID":"21697997","First.Author":"Cope","Year":"2011","Journal.Name":"Int J Chron Obstruct Pulmon Dis","Title":"Comparative efficacy of indacaterol 150 μg and 300 μg versus fixed-dose combinations of formoterol + budesonide or salmeterol + fluticasone for the treatment of chronic obstructive pulmonary disease--a network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"Dose belongs to the node and it will not be extracted."}
{"nmadb.ID":481588,"PMID":"21848493","First.Author":"Turkstra","Year":"2011","Journal.Name":"Curr Med Res Opin","Title":"A mixed treatment comparison of the short-term efficacy of biologic disease modifying anti-rheumatic drugs in established rheumatoid arthritis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"There is no information on the risk of bias domains in the supplementary material or main manuscript"}
{"nmadb.ID":501231,"PMID":"21851976","First.Author":"Cipriani","Year":"2011","Journal.Name":"Lancet","Title":"Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Webappendix Tables (pages 19 & 22)","Comment":"The dose has a quite variable scaling and it will not be extracted."}
{"nmadb.ID":482120,"PMID":"21943363","First.Author":"Hopkins","Year":"2011","Journal.Name":"BMC Musculoskelet Disord","Title":"The relative efficacy of nine osteoporosis medications for reducing the rate of fractures in post-menopausal women","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No information on the risk of bias domains was found in the supplementary material or main manuscript."}
{"nmadb.ID":482159,"PMID":"22020356","First.Author":"Klemp","Year":"2011","Journal.Name":"J Clin Psychopharmacol","Title":"A Review and Bayesian Meta-Analysis of Clinical Efficacy and Adverse Effects of 4 Atypical Neuroleptic Drugs Compared With Haloperidol and Placebo","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Risk of bias is not found in the main text or supplementary material."}
{"nmadb.ID":501298,"PMID":"22036276","First.Author":"Ibrahim","Year":"2011","Journal.Name":"J Hand Surg Am","Title":"Surgical Versus Nonsurgical Treatment of Acute Minimally Displaced and Undisplaced Scaphoid Waist Fractures: Pairwise and Network Meta-Analyses of Randomized Controlled Trials","Outcome.Type":"Subjective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 to 3","Comment":"NA"}
{"nmadb.ID":501419,"PMID":"22044854","First.Author":"Vieira","Year":"2011","Journal.Name":"HIV Clin Trials","Title":"Comparative effectiveness of efavirenz, protease inhibitors, and raltegravir-based regimens as first-line treatment for HIV-infected adults: a mixed treatment comparison.","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Patient characteristics are given per arm and are extracted so."}
{"nmadb.ID":501396,"PMID":"22142554","First.Author":"Squires","Year":"2011","Journal.Name":"Health Technol Assess","Title":"A systematic review and economic evaluation of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S3 & S4","Comment":"NA"}
{"nmadb.ID":501282,"PMID":"22151924","First.Author":"Guyot","Year":"2011","Journal.Name":"Arthritis Res Ther","Title":"Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 2","Comment":"The studies considered at least two doses of the active interventions but the review lumped the doses. Table 2 presents the characteristics for each dose, and characterstics were extracted per dose in ordered to be averaged (using weighted average) for each study. Dosing is variable: some studies report how many times per week and others every X weeks. Dosing will not be extracted. The study does not report the sample size per arm; hence, the sample sizes reported in nmadb were considered. Many multi-arm studies have been extracted as two-arm studies: the chararacteristics were averaged for the corresponding arms and considered these values to perform weighted average (characteristics are reported per arm)."}
{"nmadb.ID":481551,"PMID":"22161443","First.Author":"Gurusamy","Year":"2011","Journal.Name":"Cochrane Database Syst Rev","Title":"Methods to decrease blood loss and transfusion requirements for liver transplantation (Review)","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of studies","Comment":"NA"}
{"nmadb.ID":481163,"PMID":"21831256","First.Author":"Gallego-Galisteo","Year":"2012","Journal.Name":"J Clin Pharm Ther","Title":"Indirect comparison of biological treatments in refractory rheumatoid arthritis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Risk of bias is not found in the manuscript, nor any supplementary material."}
{"nmadb.ID":501377,"PMID":"21910698","First.Author":"Reich","Year":"2012","Journal.Name":"Br J Dermatol","Title":"Efficacy of biologics in the treatment of moderate to severe psoriasis: A network meta- analysis of randomised controlled trials","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Prior therapy' is not extractable for containing mixture of numbers and text that need expert for categorisation (if plausible). Few of the 'Patient population' characteristics can be extracted. Dose is part of the nodes."}
{"nmadb.ID":501235,"PMID":"22128085","First.Author":"Cooper","Year":"2012","Journal.Name":"Epidemiol Rev","Title":"Network Meta-analysis to Evaluate the Effectiveness of Interventions to Increase the Uptake of Smoke Alarms","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Nothing to be extracted from the Supplementary material."}
{"nmadb.ID":501418,"PMID":"22189484","First.Author":"Vejakama","Year":"2012","Journal.Name":"Diabetologia","Title":"Reno-protective effects of renin-angiotensin system blockade in type 2 diabetic patients: a systematic review and network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Table S7","Comment":"Renal function is variably measured across the trials, and hence, it will not be extracted."}
{"nmadb.ID":501253,"PMID":"22284386","First.Author":"Dunkley","Year":"2012","Journal.Name":"Diabetes Obes Metab","Title":"Effectiveness of interventions for reducing diabetes and cardiovascular disease risk in people with metabolic syndrome: systematic review and mixed treatment comparison meta-analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Table S3","Comment":"Circa half the studies do not report ethnicity and those reporting it do not report all ethnicities; ethnicity was not extracted (Table 1). Many studies are missing the standard deviation of age, and hence, this characteristic will not be extracted."}
{"nmadb.ID":482475,"PMID":"22288431","First.Author":"Gray","Year":"2012","Journal.Name":"Obes Rev","Title":"A systematic review and mixed treatment comparison of pharmacological interventions for the treatment of obesity","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Nothing to be extracted from the Supplementary material."}
{"nmadb.ID":501311,"PMID":"22292469","First.Author":"Lang","Year":"2012","Journal.Name":"Curr Med Res Opin","Title":"Treatment with tirofiban for acute coronary syndrome (ACS): a systematic review and network analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Table S3","Comment":"Patient population' was categorised into NSTE ACS, STEMI, STEMI + NSTE ACS, and ACS + non-ACS. Dose is not extracted, because for the same comparison, some studies report μg/kg and others μg/kg/min."}
{"nmadb.ID":501196,"PMID":"22340890","First.Author":"Ara","Year":"2012","Journal.Name":"Health Technol Assess","Title":"What is the clinical effectiveness and cost-effectiveness of using drugs in treating obese patients in primary care? A systematic review","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 4 & 5 (for sample size)","Comment":"Nothing to be extracted from the Supplementary material."}
{"nmadb.ID":501409,"PMID":"22393565","First.Author":"Tu","Year":"2012","Journal.Name":"J Clin Periodontol","Title":"A Bayesian network meta-analysis on comparisons of enamel matrix derivatives, guided tissue regeneration and their combination therapies","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1","Comment":"Table S1 contains only information on risk of bias domains. No information on other characteristics are found in any Appendix file."}
{"nmadb.ID":501209,"PMID":"22418856","First.Author":"Bash","Year":"2012","Journal.Name":"Cardiovasc Drugs Ther","Title":"Systematic Review and Meta-analysis of the Efficacy of Cardioversion by Vernakalant and Comparators in Patients with Atrial Fibrillation","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No supplementary material was found. Risk of bias domains are not found in the manuscript."}
{"nmadb.ID":501427,"PMID":"22443154","First.Author":"Wolff","Year":"2012","Journal.Name":"Curr Med Res Opin","Title":"Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 2","Comment":"Dose is difficult to extract for being a combination of numbers and text."}
{"nmadb.ID":501383,"PMID":"22462530","First.Author":"Roskell","Year":"2012","Journal.Name":"Curr Med Res Opin","Title":"Annualized relapse rate of first-line treatments for multiple sclerosis: a meta-analysis, including indirect comparisons versus fingolimod","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Nothing to be extracted from the Supplementary material. No information on the risk of bias domains was found in the manuscript or supplementary material. Dose in part of the nodes."}
{"nmadb.ID":501321,"PMID":"22486990","First.Author":"Liu","Year":"2012","Journal.Name":"Diabetes Obes Metab","Title":"Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: a network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1","Comment":"NA"}
{"nmadb.ID":481263,"PMID":"22505698","First.Author":"Guyot","Year":"2012","Journal.Name":"J Rheumatol","Title":"Indirect treatment comparison of abatacept with methotrexate versus other biologic agents for active rheumatoid arthritis despite methotrexate therapy in the United Kingdom","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No supplementary material, nor information on risk of bias domains were found. The dose frequency differs across studies: some report every X weeks and others X times per week. Furthermore, the dose is reported in mg in some trials and mg/kg in other trials."}
{"nmadb.ID":482476,"PMID":"22544222","First.Author":"Dumville","Year":"2012","Journal.Name":"Diabetologia","Title":"Systematic review and mixed treatment comparison: dressings to heal diabetic foot ulcers","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S3","Comment":"NA"}
{"nmadb.ID":480721,"PMID":"22582102","First.Author":"Stam","Year":"2012","Journal.Name":"Open Rheumatol J","Title":"Efficacy of Etoricoxib, Celecoxib, Lumiracoxib, Non-Selective NSAIDs, and Acetaminophen in Osteoarthritis: A Mixed Treatment Comparison","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Only the name of the scale was extracted. No supplementary material nor information on risk of bias domains. Dose is part of the nodes."}
{"nmadb.ID":501339,"PMID":"22592688","First.Author":"Mhaskar","Year":"2012","Journal.Name":"Cochrane Database Syst Rev","Title":"Bisphosphonates in multiple myeloma: a network meta- analysis (Review)","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies & Appendix Table 4","Comment":"NA"}
{"nmadb.ID":480430,"PMID":"22700784","First.Author":"Gómez-Outes","Year":"2012","Journal.Name":"BMJ","Title":"Dabigatran, rivaroxaban, or apixaban versus enoxaparin for thromboprophylaxis after total hip or knee replacement: systematic review, meta-analysis, and indirect treatment comparisons","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"For some interventions, there is a detailed dosage outline that needs expert opinion to extract. Dose will not be extracted."}
{"nmadb.ID":501319,"PMID":"22717535","First.Author":"Littlewood","Year":"2012","Journal.Name":"J Cyst Fibros","Title":"A network meta-analysis of the efficacy of inhaled antibiotics for chronic Pseudomonas infections in cystic fibrosis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"NA"}
{"nmadb.ID":501240,"PMID":"22732017","First.Author":"Cope","Year":"2012","Journal.Name":"BMC Pulm Med","Title":"Efficacy of once-daily indacaterol 75 mug relative to alternative bronchodilators in COPD: A study level and a patient level network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"Dose belongs to the node and it will not be extracted."}
{"nmadb.ID":501325,"PMID":"23043126","First.Author":"Mak","Year":"2012","Journal.Name":"BMJ Open","Title":"Coronary and mortality risk of novel oral antithrombotic agents: a meta-analysis of large randomised trials","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Therapy duration is variably measured as mean, median, total months, days range, years, months, and it will not be extracted."}
{"nmadb.ID":501228,"PMID":"23046909","First.Author":"Chen","Year":"2012","Journal.Name":"Health Technol Assess","Title":"Effectiveness and cost-effectiveness of computer and other electronic aids for smoking cessation: a systematic review and network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 5 to 8","Comment":"NA"}
{"nmadb.ID":501283,"PMID":"23048010","First.Author":"Haas","Year":"2012","Journal.Name":"BMJ","Title":"Tocolytic therapy for preterm delivery: systematic review and network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1","Comment":"Only risk of bias domains were reported, and no patient or intervention characteristics."}
{"nmadb.ID":501318,"PMID":"23069736","First.Author":"Lin","Year":"2012","Journal.Name":"Arch Dermatol","Title":"Comparison of Ustekinumab With Other Biological Agents for the Treatment of Moderate to Severe Plaque Psoriasis A Bayesian Network Meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 2","Comment":"dose is reported as mg in some trials and mg/kg in other trials, and it will not be extracted."}
{"nmadb.ID":501204,"PMID":"23102749","First.Author":"Bally","Year":"2012","Journal.Name":"Int J Antimicrob Agents","Title":"A network meta-analysis of antibiotics for treatment of hospitalised patients with suspected or proven meticillin-resistant Staphylococcus aureus infection","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1, Table S1","Comment":"% diabetes is variably measured across the trials (see the legend a-g), and it will not be extracted. % ventilator-associated pneumonia has missing data in almost all trials and it will not be extracted"}
{"nmadb.ID":501263,"PMID":"23150473","First.Author":"Fox","Year":"2012","Journal.Name":"BMJ","Title":"Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: direct and adjusted indirect meta-analysis of randomised controlled trials","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"NA"}
{"nmadb.ID":501200,"PMID":"23205332","First.Author":"Baker","Year":"2012","Journal.Name":"Dermatol Ther","Title":"Effect of Biologic Agents on Non-PASI Outcomes in Moderate-to-Severe Plaque Psoriasis: Systematic Review and Meta-Analyses","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Baseline PASI is provided per arm, not per study. The maximum dose was extracted when the active arm was reported in more doses."}
{"nmadb.ID":501379,"PMID":"22192281","First.Author":"Ribeiro","Year":"2013","Journal.Name":"Int J Cardiol","Title":"Impact of statin dose on major cardiovascular events: A mixed treatment comparison meta-analysis involving more than 175,000 patients","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Only four characteristics and no risk of bias domain (no supplementary material was found). Patient characteristics are too variable to be meaningfully extracted."}
{"nmadb.ID":501403,"PMID":"22703832","First.Author":"Terasawa","Year":"2013","Journal.Name":"Cancer Treat Rev","Title":"Comparative efficacy of first-line therapies for advanced-stage chronic lymphocytic leUnited Kingdomemia: A multiple-treatment meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 & S3","Comment":"Some data from Table 2 could be extracted (e.g., frequency of follow-up) but there are too many missing data."}
{"nmadb.ID":479918,"PMID":"22776828","First.Author":"Gao","Year":"2013","Journal.Name":"Epilepsy Res","Title":"Clinical efficacy and safety of the newer antiepileptic drugs as adjunctive treatment in adults with refractory partial-onset epilepsy: A meta-analysis of randomized placebo-controlled trials","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Patient characteristics are summarised by different doses of each intervention, but the interventions are analysed after lumping their doses. Only a few trial-specific characteristics were extracted."}
{"nmadb.ID":501391,"PMID":"22958381","First.Author":"Scott","Year":"2013","Journal.Name":"Diabetes Obes Metab","Title":"A network meta-analysis to compare glycaemic control in patients with type 2 diabetes treated with exenatide once weekly or liraglutide once daily in comparison with insulin glargine, exenatide twice daily, or placebo","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Background therapy' has too many categories. No information on the risk of bias domains was found in manuscript or supplementary material."}
{"nmadb.ID":501307,"PMID":"22972856","First.Author":"Krogh","Year":"2013","Journal.Name":"Am J Sports Med","Title":"Comparative Effectiveness of Injection Therapies in Lateral Epicondylitis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1 & 2","Comment":"Dosing and inclusion criteria are a mixture of text and numbers and were not be extracted."}
{"nmadb.ID":501251,"PMID":"23042705","First.Author":"Dong","Year":"2013","Journal.Name":"Thorax","Title":"Comparative safety of inhaled medications in patients with chronic obstructive pulmonary disease: systematic review and mixed treatment comparison meta-analysis of randomised controlled trials","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 to S3","Comment":"NA"}
{"nmadb.ID":501317,"PMID":"23057701","First.Author":"Lin","Year":"2013","Journal.Name":"J Clin Periodontol","Title":"In-office treatment for dentin hypersensitivity: a systematic review and network meta-analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 2","Comment":"The supplementary Table 1 repeats Table 2. No information on risk of bias domains were found."}
{"nmadb.ID":501227,"PMID":"23325883","First.Author":"Chatterjee","Year":"2013","Journal.Name":"BMJ","Title":"Benefits of β blockers in patients with heart failure and reduced ejection fraction: network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Supplementary Table B","Comment":"Supplementary Table A has a mixture of text and numbers and needs expert opinion for categorisation (if applicable)."}
{"nmadb.ID":501220,"PMID":"23346965","First.Author":"Buti","Year":"2013","Journal.Name":"J Clin Periodontol","Title":"Bayesian network meta-analysis of root coverage procedures: ranking efficacy and identification of best treatment.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No supplementary material was found. No information on the sample size in the article or nmadb."}
{"nmadb.ID":501214,"PMID":"23351090","First.Author":"Bodalia","Year":"2013","Journal.Name":"Br J Clin Pharmacol","Title":"Comparative Efficacy and Tolerability of Antiepileptic Drugs for Refractory Focal Epilepsy","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Tables 1 & S4","Comment":"NA"}
{"nmadb.ID":501435,"PMID":"23395275","First.Author":"Yuan","Year":"2013","Journal.Name":"Eur Urol","Title":"Comparative effectiveness and safety of oral phosphodiesterase type 5 inhibitors for erectile dysfunction: a systematic review and network meta-analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 & S2","Comment":"It is not clear if the mean or median is reported alongside the range. Extracted data may not be accurate."}
{"nmadb.ID":501388,"PMID":"23413913","First.Author":"Samarasekera","Year":"2013","Journal.Name":"Br J Dermatol","Title":"Topical therapies for the treatment of plaque psoriasis: systematic review and network meta-analyses.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 (sample size) & Table S2a & S2b","Comment":"Inclusion criteria have heterogeneous information that is difficult to extract or categorise. No information on risk of bias domains was found in the main or supplementary material."}
{"nmadb.ID":501338,"PMID":"23422286","First.Author":"Mealing","Year":"2013","Journal.Name":"Exp Hematol Oncol","Title":"The relative efficacy of imatinib, dasatinib and nilotinib for newly diagnosed chronic myeloid leUnited Kingdomemia: a systematic review and network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"NA"}
{"nmadb.ID":479807,"PMID":"23442134","First.Author":"Galvan-Banqueri","Year":"2013","Journal.Name":"J Clin Pharm Ther","Title":"Biological treatments for moderate-to-severe psoriasis: indirect comparison","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Previous treatment' (topical, phototherapy, conventional systemic and biological) is not observed in most trials, leading to many missing data. This characteristic will be extracted only on topical that is included in most trials."}
{"nmadb.ID":482109,"PMID":"23519234","First.Author":"Kwok","Year":"2013","Journal.Name":"Chest","Title":"Relative Effects of Two Different Enoxaparin Regimens as Comparators Against Newer Oral Anticoagulants: Meta-analysis and Adjusted Indirect Comparison","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Both","Source.ToC":"Table 1 & e-Table 1","Comment":"NA"}
{"nmadb.ID":482016,"PMID":"23538193","First.Author":"Cope","Year":"2013","Journal.Name":"Value Health","Title":"Progression-Free Survival with Fulvestrant 500 mg and Alternative Endocrine Therapies as Second-Line Treatment for Advanced Breast Cancer: A Network meta-Analysis with Parametric Survival Models","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"No supplementary material was found. Dose is part of the node and it will not be extracted."}
{"nmadb.ID":501281,"PMID":"23550994","First.Author":"Gupta","Year":"2013","Journal.Name":"Br J Dermatol","Title":"Network meta-analysis of the outcome 'participant complete clearance' in nonimmunosuppressed participants ofeight interventions for actinic keratosis: a follow-up on a Cochrane review.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 & S2","Comment":"Severity and interventon frequency are heterogeneously reported across the trials. Supplementary figure on risk of bias is provided as eps and cannot be read."}
{"nmadb.ID":501384,"PMID":"23553036","First.Author":"Rotta","Year":"2013","Journal.Name":"JAMA Dermatol","Title":"Efficacy of topical antifungals in the treatment of dermatophytosis: a mixed-treatment comparison meta-analysis involving 14 treatments.","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"eTable 2a & 2b","Comment":"In some trials, the total in nmadb in larger than that reported. The extracted sample size my be inaccurate."}
{"nmadb.ID":481766,"PMID":"23623245","First.Author":"Zaccara","Year":"2013","Journal.Name":"Seizure","Title":"Neurological adverse events of new generation sodium blocker antiepileptic drugs. Meta-analysis of randomized, double-blinded studies with eslicarbazepine acetate, lacosamide and oxcarbazepine","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Suppl. Document 2","Comment":"Best efforts were made to extract as much as possible as the information is provided in text."}
{"nmadb.ID":501305,"PMID":"23659562","First.Author":"Khan","Year":"2013","Journal.Name":"Curr Med Res Opin","Title":"The efficacy and tolerability of perampanel and other recently approved anti-epileptic drugs for the treatment of refractory partial onset seizure: a systematic review and Bayesian network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No supplementary material was found."}
{"nmadb.ID":482129,"PMID":"23680885","First.Author":"Pandor","Year":"2013","Journal.Name":"Heart","Title":"Remote monitoring after recent hospital discharge in patients with heart failure: a systematic review and network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Both","Source.ToC":"Tables 1 & S2","Comment":"Table 1 is fully textual, making extraction very challenging. Only risk of bias domains (Table S2), country and sites (Table 1) are extractable."}
{"nmadb.ID":501225,"PMID":"23686477","First.Author":"Cawston","Year":"2013","Journal.Name":"Eur Spine","Title":"Efficacy of duloxetine versus alternative oral therapies: an indirect comparison of randomised clinical trials inchronic low back pain.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 2 & 3","Comment":"No supplementary material was found."}
{"nmadb.ID":479603,"PMID":"23700633","First.Author":"Shamliyan","Year":"2013","Journal.Name":"AHRQ","Title":"Migraine in Adults: Preventive Pharmacologic Treatments Preventive Pharmacologic Treatments","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables D15 and onwards","Comment":"Definition of migraine' is textual, '% without aura' and 'baseline severity' was missing in almost all trials. Some trials were mispelled and for other the total sample size was lower than the analysed in nmadb. The extraction is very likely not 100% accurate due to reporting typos/inaccuracies in the systematic review."}
{"nmadb.ID":501392,"PMID":"23725530","First.Author":"Shi","Year":"2013","Journal.Name":"Eur J Clin Invest","Title":"Secondary prophylaxis of variceal bleeding for cirrhotic patients: a multiple-treatments meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Figure S3","Comment":"Only risk of bias domains were extracted."}
{"nmadb.ID":501212,"PMID":"23734288","First.Author":"Biondi-Zoccai","Year":"2013","Journal.Name":"HSR Proc Intensive Care Cardiovasc Anesth","Title":"Comparative effectiveness of novel oral anticoagulants for atrial fibrillation: evidence from pair-wise and warfarin-controlled network meta-analyses.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Tables 2, 4 & 5","Comment":"Information on 'Drug' is a mixture of text and numbers."}
{"nmadb.ID":501261,"PMID":"23744561","First.Author":"Filippini","Year":"2013","Journal.Name":"Cochrane Database Syst Rev","Title":"Immunomodulators and immunosuppressants for multiple sclerosis: a network meta-analysis (Review)","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies","Comment":"Best efforts were made to extract as much as possible as the information is provided in textual format."}
{"nmadb.ID":501351,"PMID":"23838105","First.Author":"Naci","Year":"2013","Journal.Name":"Circ Cardiovasc Qual Outcomes","Title":"Comparative Tolerability and Harms of Individual Statins: A Study-Level Network Meta-Analysis of 246 955 Participants From 135 Randomized, Controlled Trials","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1 & S2","Comment":"Mean age and baseline LDL are summarised per arm."}
{"nmadb.ID":501216,"PMID":"23840824","First.Author":"Braun","Year":"2013","Journal.Name":"PLoS One","Title":"Comparing bona fide psychotherapies of depression in adults with two meta-analytical approaches","Outcome.Type":"Subjective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1 & S2 (for sample size)","Comment":"NA"}
{"nmadb.ID":501199,"PMID":"23870607","First.Author":"Assiri","Year":"2013","Journal.Name":"Clin Ther","Title":"Mixed Treatment Comparison Meta-Analysis of Aspirin,Warfarin, and New Anticoagulants for Stroke Prevention in Patients With Nonvalvular Atrial Fibrillation","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Tables 3 & S2","Comment":"Three studies include interventions not found in the study (triflusal and idraparinux): Bousser 2008, Pérez-Gómez 2004, and Pérez-Gómez 2004 (B). These studies were excluded."}
{"nmadb.ID":501224,"PMID":"23996149","First.Author":"Castellucci","Year":"2013","Journal.Name":"BMJ","Title":"Efficacy and safety outcomes of oral anticoagulants and antiplatelet drugs in the secondary prevention of venous thromboembolism: systematic review and network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Tables 1 & Appendix 3","Comment":"Table 1 has many arm-based characteristics."}
{"nmadb.ID":501269,"PMID":"24046285","First.Author":"Gagne","Year":"2013","Journal.Name":"BMJ","Title":"Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Appendix table","Comment":"Appendix table has only the risk of bias domain (extractable) and Table 1 is not extractable: patient population is a mixture of text and numbers and only the follow-up and sample size are extractable."}
{"nmadb.ID":501320,"PMID":"24098546","First.Author":"Liu","Year":"2013","Journal.Name":"PLoS One","Title":"Comparative efficacy and Accebtability of Antidepressants in Parkinson's Disease: A Network Meta-Analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1","Comment":"Hoehn and Yahr stage' is reported as number in some studies (mean/median) and as text in others. It will not be extracted."}
{"nmadb.ID":480492,"PMID":"24126676","First.Author":"Meissner","Year":"2013","Journal.Name":"JAMA Intern Med","Title":"Differential Effectiveness of Placebo Treatments A Systematic Review of Migraine Prophylaxis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"eTable 2","Comment":"NA"}
{"nmadb.ID":501194,"PMID":"24138390","First.Author":"Akshintala","Year":"2013","Journal.Name":"Aliment Pharmacol Ther","Title":"Systematic review with network meta-analysis: pharmacological prophylaxis against post-ERCP pancreatitis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S2 & Figure S1","Comment":"Some of the characteristic in Table S2 are reported per arm."}
{"nmadb.ID":501431,"PMID":"24157497","First.Author":"Wu","Year":"2013","Journal.Name":"BMJ","Title":"Comparative effectiveness of renin-angiotensin system blockers and other antihypertensive drugs in patients with diabetes: systematic review and bayesian network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Supplementary Table B","Comment":"NA"}
{"nmadb.ID":482760,"PMID":"24160565","First.Author":"Naudet","Year":"2013","Journal.Name":"BMC Med","Title":"Which placebo to cure depression? A thought-provoking network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & e-Table 1","Comment":"Table 1 summarises the characteristics per comparison, and e-Table 1 has the risk of bias domains only. No information on the sample size in the article or nmadb."}
{"nmadb.ID":481781,"PMID":"24166666","First.Author":"Chatterjee","Year":"2013","Journal.Name":"JAMA Neurol","Title":"New Oral Anticoagulants and the Risk of Intracranial Hemorrhage Traditional and Bayesian Meta-analysis and Mixed Treatment Comparison of Randomized Trials of New Oral Anticoagulants in Atrial Fibrillation","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Both","Source.ToC":"Table 1 & eTable","Comment":"No information on the exact risk of bias items in eTable."}
{"nmadb.ID":501361,"PMID":"24166910","First.Author":"Palmieri","Year":"2013","Journal.Name":"Clin Cancer Res","Title":"Comparative Efficacy of Bisphosphonates in Metastatic Breast and Prostate Cancer and Multiple Myeloma: A Mixed-Treatment Meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No supplementary material was found."}
{"nmadb.ID":501223,"PMID":"24176098","First.Author":"Carroll","Year":"2013","Journal.Name":"Health Technol Assess","Title":"Clinical effectiveness and cost-effectiveness of minimally invasive techniques to manage varicose veins: a systematic review and economic evaluation","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Tables 2 to 10","Comment":"Characteristics are presented per arm."}
{"nmadb.ID":481384,"PMID":"24220600","First.Author":"Schoenberg","Year":"2013","Journal.Name":"Ann Surg","Title":"Laparoscopic Heller myotomy versus endoscopic balloon dilatation for the treatment of achalasia: a network meta-analysis.","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Both","Source.ToC":"Tables 2 to 4 & Suppl Figure","Comment":"For some trials no scale is reported for symptoms duration and follow up, making the extraction likely inaccurate for these characteristics."}
{"nmadb.ID":481470,"PMID":"23790149","First.Author":"Carter","Year":"2014","Journal.Name":"J Hum Nutr Diet","Title":"A Mediterranean diet improves HbA1c but not fasting blood glucose compared to alternative dietary strategies: a network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"There is no supplementary material, nor any risk of bias domain in the main article. 'Patient information', and diet description are a mixture of text and number, making it difficult to extract the relevant information."}
{"nmadb.ID":482382,"PMID":"23888328","First.Author":"Shams","Year":"2014","Journal.Name":"J Gen Intern Med","Title":"SSRIs for Hot Flashes: A Systematic Review and Meta-Analysis of Randomized Trials","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"No dosage is mentioned for citalopram studies"}
{"nmadb.ID":481140,"PMID":"23919914","First.Author":"Kunitomi","Year":"2014","Journal.Name":"Br J Clin Pharmacol","Title":"Indirect comparison analysis of efficacy and safety between olanzapine and aripiprazole for schizophrenia","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Risk of bias domains not reported in main article or supplementary material."}
{"nmadb.ID":501229,"PMID":"23964810","First.Author":"Chilton","Year":"2014","Journal.Name":"Diabetes Obes Metab","Title":"The effect of antiobesity drugs on waist circumference: a mixed treatment comparison","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"NA"}
{"nmadb.ID":501252,"PMID":"23971722","First.Author":"Dooley","Year":"2014","Journal.Name":"Curr Med Res Opin","Title":"Comparison of the efficacy and safety of low molecular weight heparins for venous thromboembolism prophylaxis in medically ill patients","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No supplementary material was found. 'Prophylaxis indication' is textual and difficult to extract. Patient characteristics are reported per arm."}
{"nmadb.ID":501363,"PMID":"23975736","First.Author":"Pechlivanoglou","Year":"2014","Journal.Name":"J Antimicrob Chemother","Title":"Mixed treatment comparison of prophylaxis against invasive fungal infections in neutropenic patients receiving therapy for haematological malignancies: a systematic review","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 & S2","Comment":"Patient characteristics are reported per arm."}
{"nmadb.ID":501250,"PMID":"24009224","First.Author":"Dogliotti","Year":"2014","Journal.Name":"Heart","Title":"Current and new oral antithrombotics in non-valvular atrial fibrillation: a network meta-analysis of 79 808 patients","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"Drug discontinuation' is reported per arm. Risk of bias domains were not found (also after inspecting the supplementary material), except for 'blinding' in Table 1."}
{"nmadb.ID":481418,"PMID":"24083626","First.Author":"Chen","Year":"2014","Journal.Name":"Curr Med Res Opin","Title":"Long-term clinical efficacy and safety of adding cilostazol to dual antiplatelet therapy for patients undergoing PCI: a meta-analysis of randomized trials with adjusted indirect comparisons","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Characteristics are presented per arm. Dose and dose duration could not be extracted because the intervention are analysed after lumping, and Table 1 gives this information for each compound. Risk of bias domains could not be extracted because this information is given as a barplot."}
{"nmadb.ID":480693,"PMID":"24131260","First.Author":"Schmitt","Year":"2014","Journal.Name":"Br J Dermatol","Title":"Efficacy and safety of systemic treatments for moderate-to-severe psoriasis: meta-analysis of randomized controlled trials","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Intervention doses are analysed; hence, dose is not considered. There is no access to the supplementary material to extract Table S1 (Summary of study inclusion criteria and baseline characteristics)."}
{"nmadb.ID":482415,"PMID":"24444390","First.Author":"Dranitsaris","Year":"2014","Journal.Name":"J Eval Clin Pract","Title":"Sublingual or subcutaneous immunotherapy for seasonal allergic rhinitis: an indirect analysis of efficacy, safety and cost","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No supplementary material was found. Risk of bias domains are not reported. Age is reported per arm."}
{"nmadb.ID":480666,"PMID":"24448972","First.Author":"Kriston","Year":"2014","Journal.Name":"Depress Anxiety","Title":"Efficacy and acceptability of acute treatments for persistent depressive disorder: a network meta-analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"eTable 4 & eTable 5","Comment":"Details' are a mixture of text and numbers (interventions and counseling)."}
{"nmadb.ID":482006,"PMID":"24513112","First.Author":"Lin","Year":"2014","Journal.Name":"J Dent","Title":"Primary molar pulpotomy: A systematic review and network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"Several 'Follow-up period' are reported and the maximum was extracted."}
{"nmadb.ID":480695,"PMID":"24551100","First.Author":"Yang","Year":"2014","Journal.Name":"PLoS One","Title":"Efficacy and Safety of Therapies for Acute Ischemic Stroke in China: A Network Meta-Analysis of 13289 Patients from 145 Randomized Controlled Trials","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1 & Excel file","Comment":"Neurological deficit score' is reported per arm."}
{"nmadb.ID":481733,"PMID":"24576593","First.Author":"Yang","Year":"2014","Journal.Name":"Int J Surg","Title":"A network meta-analysis on the efficacy of 5-aminosalicylates,immunomodulators and biologics for the prevention of postoperative recurrence in Crohn's disease","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Tables 1 & S1","Comment":"Some patient characteristics are provided per arm but it is no indicated in Table S1 for which arm; in the extraction,the first arm was considered as the control (possible limitation). Risk of bias domains are not reported in the main manuscript or the supplementary material."}
{"nmadb.ID":481118,"PMID":"24602249","First.Author":"Mealing","Year":"2014","Journal.Name":"Syst Rev","Title":"The importance of baseline viral load when assessing relative efficacy in treatment-naïve HBeAg-positive chronic hepatitis B: a systematic review and network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Additional file 1 (Table S1)","Comment":"LLOQ' described as 'copies/ml' in some studies and as 'pq/ml' in other studies. Dose is included in the treatment node."}
{"nmadb.ID":479971,"PMID":"24617578","First.Author":"Loke","Year":"2014","Journal.Name":"Br J Clin Pharmacol","Title":"Comparative coronary risks of apixaban, rivaroxaban and dabigatran: a meta-analysis and adjusted indirect comparison","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S2 & S3","Comment":"Follow-up' is measured as median, mean and number of days/years/months, and hence, the extraction cannot be precise. Only risk of bias domains and sample size are extractable."}
{"nmadb.ID":480720,"PMID":"24618328","First.Author":"Myers","Year":"2014","Journal.Name":"BMC Musculoskelet Disord","Title":"The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a systematic literature review and meta-analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"NA"}
{"nmadb.ID":482440,"PMID":"24627974","First.Author":"Roskell","Year":"2014","Journal.Name":"Curr Med Res Opin","Title":"Systematic evidence synthesis of treatments for ADHD in children and adolescents: indirect treatment comparisons of lisdexamfetamine with methylphenidate and atomoxetine","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S5 & S7","Comment":"dose' is variably reported: some studies report mg/kg/day and others mg or mg/day"}
{"nmadb.ID":480563,"PMID":"24659260","First.Author":"Caldeira","Year":"2014","Journal.Name":"Am J Cardiovasc Drugs","Title":"Dyspnea and Reversibility Profile of P2Y12 Antagonists: Systematic Review of New Antiplatelet Drugs","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Appendix figure","Comment":"Follow-up is very heterogeneously reported, as some studies report in months, other in weeks, days and hours."}
{"nmadb.ID":479767,"PMID":"24661896","First.Author":"Katsanos","Year":"2014","Journal.Name":"J Vasc Surg","Title":"Bayesian network meta-analysis of nitinolstents, covered stents, drug-eluting stents, anddrug-coated balloons in the femoropopliteal artery","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Both","Source.ToC":"Figure 2 & Tables S1 & S2","Comment":"Recommended antiplatelet therapy' is heterogeneously reported across the trials."}
{"nmadb.ID":479993,"PMID":"24664619","First.Author":"Craddy","Year":"2014","Journal.Name":"Diabetes Ther","Title":"Comparative Effectiveness of Dipeptidylpeptidase-4 Inhibitors in Type 2 Diabetes: A Systematic Review and Mixed Treatment Comparison","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix 3 & Excel file","Comment":"Some trials report '% female', 'mean age', and 'diabetes duration' per arm. Nodes comprise of multiple interventions with their doses, making dose extraction challenging. For some components dosing is not reported. Dose and dosing will not be extracted! When it is not mentioned the multicenter status of the study, it is unknown if this study is singlecenter or this information is NA. Multicenter status will not be extracted. Same for the phase status. There is no reference for studies that appear more than once, which may lead to wrong extraction for the risk of bias domains."}
{"nmadb.ID":481412,"PMID":"24671923","First.Author":"Kew","Year":"2014","Journal.Name":"Cochrane Database Syst Rev","Title":"Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis (Review)","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies & Additional table 1","Comment":"NA"}
{"nmadb.ID":482258,"PMID":"24687313","First.Author":"Price","Year":"2014","Journal.Name":"BMJ","Title":"Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care: systematic review and network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1 to 6","Comment":"Risk of bias domain, sample size, and country are only extractable."}
{"nmadb.ID":482734,"PMID":"24697518","First.Author":"Furukawa","Year":"2014","Journal.Name":"Acta Psychiatr Scand","Title":"Waiting list may be a nocebo condition in psychotherapy trials: a contribution from network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No supplementary material was found. Risk of bias domains are reported in barplot."}
{"nmadb.ID":482465,"PMID":"24698515","First.Author":"Snedecor","Year":"2014","Journal.Name":"Int J Clin Pract","Title":"Systematic review and meta-analysis of pharmacological therapies for pain associated with postherpetic neuralgia and less common neuropathic conditions","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 2 & Appendix A","Comment":"NA"}
{"nmadb.ID":482521,"PMID":"24749763","First.Author":"Stidham","Year":"2014","Journal.Name":"Aliment Pharmacol Ther","Title":"Systematic review with network meta-analysis: the efficacy of anti-TNF agents for the treatment of Crohn's disease","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"No supplementary material was found. Risk of bias domains are not reported."}
{"nmadb.ID":481159,"PMID":"24773456","First.Author":"Ellis","Year":"2014","Journal.Name":"Curr Med Res Opin","Title":"Indirect comparison of bazedoxifene vs oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No supplementary material was found. Risk of bias domain are not reported."}
{"nmadb.ID":482745,"PMID":"24831822","First.Author":"Leaviss","Year":"2014","Journal.Name":"Health Technol Assess","Title":"What is the clinical effectiveness and cost-effectiveness of cytisine compared with varenicline for smoking cessation? A systematic review and economic evaluation","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 to 3","Comment":"Patient characteristics are reported per arm. Other patient and intervention characteristics were a mixture of text and number, rendering extraction challenging."}
{"nmadb.ID":480029,"PMID":"24833678","First.Author":"Xiong","Year":"2014","Journal.Name":"BMJ open","Title":"Comparative efficacy and safety of treatments for localised prostate cancer: an application of network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Both","Source.ToC":"Figure 2 & Table S2","Comment":"NA"}
{"nmadb.ID":479816,"PMID":"24869750","First.Author":"Musini","Year":"2014","Journal.Name":"Cochrane Database Syst Rev","Title":"Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies","Comment":"Almost all extracted trias are multi-arms trials, clinical characteristics, such as blood pressure, are reported for the 'active' and 'control' treatment (two values). Placebo was considered to be the control and the same value was used for all other treatments being the 'active'. This is a limitation."}
{"nmadb.ID":479999,"PMID":"24919052","First.Author":"Loymans","Year":"2014","Journal.Name":"BMJ","Title":"Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 & S2","Comment":"NA"}
{"nmadb.ID":479652,"PMID":"24944120","First.Author":"Leibovici-Weissman","Year":"2014","Journal.Name":"Cochrane Database Syst Rev","Title":"Antimicrobial drugs for treating cholera (Review)","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included trials","Comment":"Follow up duration is reported as text in some trials and as number in others. It will not be extracted."}
{"nmadb.ID":482156,"PMID":"24958153","First.Author":"Windecker","Year":"2014","Journal.Name":"BMJ","Title":"Revascularisation versus medical treatment in patients with stable coronary artery disease: network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1","Comment":"NA"}
{"nmadb.ID":481150,"PMID":"24965841","First.Author":"Laporte","Year":"2014","Journal.Name":"Thromb Haemost","Title":"Indirect comparison meta-analysis of two enoxaparin regimens in patients undergoing major orthopaedic surgery. Impact on the interpretation of thromboprophylactic effects of new anticoagulant drugs.","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 & S2","Comment":"NA"}
{"nmadb.ID":479773,"PMID":"24969003","First.Author":"Ellis","Year":"2014","Journal.Name":"Value Health","Title":"Bazedoxifene versus Oral Bisphosphonates for the Prevention of Nonvertebral Fractures in Postmenopausal Women with Osteoporosis at Higher Risk of Fracture: A Network Meta-Analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"There is no information about the risk of bias domains in the supplementary material or main manuscript."}
{"nmadb.ID":480039,"PMID":"24988902","First.Author":"Jansen","Year":"2014","Journal.Name":"Health Qual Life Outcomes","Title":"Comparative efficacy of biologics as monotherapy and in combination with methotrexate on patient reported outcomes (PROs) in rheumatoid arthritis patients with an inadequate response to conventional DMARDs - a systematic review and network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"There is no information on the risk of bias domains in the supplementary material or main manuscript."}
{"nmadb.ID":482477,"PMID":"25006351","First.Author":"Orme","Year":"2014","Journal.Name":"Diabetol Metab Syndr","Title":"A systematic review and mixed-treatment comparison of dapagliflozin with existing anti-diabetes treatments for those with type 2 diabetes mellitus inadequately controlled by sulfonylurea monotherapy","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 2, Table A.3 and Additional file 4","Comment":"Dose is considered in the network plot and the analysis (no lumping). Participant characteristics are reported per arm."}
{"nmadb.ID":480706,"PMID":"25029255","First.Author":"Regnier","Year":"2014","Journal.Name":"PLoS One","Title":"Efficacy of Anti-VEGF and Laser Photocoagulation in the Treatment of Visual Impairment due to Diabetic Macular Edema: A Systematic Review and Network Meta-Analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Table S5","Comment":"NA"}
{"nmadb.ID":482451,"PMID":"25039292","First.Author":"Faggion","Year":"2014","Journal.Name":"J Clin Periodontol","Title":"A systematic review and Bayesian network meta-analysis of randomized clinical trials on non-surgical treatments for peri-implantitis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Figure S.3","Comment":"Table 1 is fully textual, making extraction very challenging. Only risk of bias domains (Figure S.3) and sample size are extractable."}
{"nmadb.ID":480931,"PMID":"25047428","First.Author":"Rochwerg","Year":"2014","Journal.Name":"Ann Intern Med","Title":"Fluid Resuscitation in Sepsis: A Systematic Review and Network Meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Appendix table","Comment":"Intervention period and dose are variably measured across the studies (mL or mL/kg)."}
{"nmadb.ID":481583,"PMID":"25050588","First.Author":"Sun","Year":"2014","Journal.Name":"Curr Med Res Opin","Title":"A mixed treatment comparison of gabapentin enacarbil, pramipexole, ropinirole and rotigotine in moderate-to-severe restless legs syndrome","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & Appendix","Comment":"NA"}
{"nmadb.ID":481856,"PMID":"25086573","First.Author":"Le Cleach","Year":"2014","Journal.Name":"Cochrane Database Syst Rev","Title":"Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients (Review)","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies","Comment":"NA"}
{"nmadb.ID":481836,"PMID":"25114521","First.Author":"Roskell","Year":"2014","Journal.Name":"Int J Chron Obstruct Pulmon Dis","Title":"Once-daily long-acting beta-agonists for chronic obstructive pulmonary disease: an indirect comparison of olodaterol and indacaterol","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1, Tables A2 & A3","Comment":"Participant characteristics are reported by arm."}
{"nmadb.ID":473269,"PMID":"25184309","First.Author":"Lin","Year":"2014","Journal.Name":"Ann Pharmacother","Title":"Comparative Efficacy and Tolerability of Topical Prostaglandin Analogues for Primary Open-Angle Glaucoma and Ocular Hypertension","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Table 1 & Figure 2","Comment":"NA"}
{"nmadb.ID":479531,"PMID":"25188312","First.Author":"Patel","Year":"2014","Journal.Name":"PLoS One","Title":"48-Week Efficacy and Safety of Dolutegravir Relative to Commonly Used Third Agents in Treatment-Naive HIV-1- Infected Patients: A Systematic Review and Network Meta-Analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1","Comment":"Risk of bias domains are not reported in the supplementary material or the manuscript. Characteristics are reported per arm."}
{"nmadb.ID":480001,"PMID":"25224562","First.Author":"Nagayama","Year":"2014","Journal.Name":"J Natl Cancer Inst","Title":"Comparative Effectiveness of Neoadjuvant Therapy for HER2-Positive Breast Cancer: A Network Meta-Analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Both","Source.ToC":"Tables 1 & S1","Comment":"Clinical stage is too variably reported across the trials to be extracted."}
{"nmadb.ID":474842,"PMID":"25226478","First.Author":"Castellucci","Year":"2014","Journal.Name":"JAMA","Title":"Clinical and Safety Outcomes Associated With Treatment of Acute Venous Thromboembolism A Systematic Review and Meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Both","Source.ToC":"Tables 1 to 4 and Appendix","Comment":"NA"}
{"nmadb.ID":481511,"PMID":"25242363","First.Author":"Piccolo","Year":"2014","Journal.Name":"Am J Cardiol","Title":"Meta-Analysis of Randomized Trials Comparing the Effectiveness of Different Strategies for the Treatment of Drug-Eluting Stent Restenosis","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Both","Source.ToC":"Tables 1 & S1","Comment":"Some participant characteristics are reported per arm"}
{"nmadb.ID":482117,"PMID":"25249164","First.Author":"Llorca","Year":"2014","Journal.Name":"Curr Med Res Opin","Title":"Relative efficacy and tolerability of vortioxetine versus selected antidepressants by indirect comparisons of similar clinical studies","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 2","Comment":"No supplementary material was found. Risk of bias domains are not reported."}
{"nmadb.ID":481731,"PMID":"25276771","First.Author":"Peruzzi","Year":"2014","Journal.Name":"Biomed Res Int","Title":"A Network Meta-Analysis on Randomized Trials Focusing on the Preventive Effect of Statins on Contrast-Induced Nephropathy","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 to 3","Comment":"NA"}
{"nmadb.ID":479757,"PMID":"25286060","First.Author":"Chan","Year":"2014","Journal.Name":"PLoS One","Title":"A Bayesian Meta-Analysis of Multiple Treatment Comparisons of Systemic Regimens for Advanced Pancreatic Cancer","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix 2 & 15","Comment":"NA"}
{"nmadb.ID":481195,"PMID":"25332702","First.Author":"Fournier","Year":"2014","Journal.Name":"Ger Med Sci","Title":"Indirect comparison of lixisenatide versus neutral protamine Hagedorn insulin as add-on to metformin and sulphonylurea in patients with type 2 diabetes mellitus","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Risk of bias domains are not reported in the supplementary material or the main manuscript. Participant characteristics are reported per arm."}
{"nmadb.ID":482450,"PMID":"25361361","First.Author":"Cui","Year":"2014","Journal.Name":"Orthopedics","Title":"A Systematic Review and Adjusted Indirect Comparison of Oral Anticoagulants","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"For some trials, dose description is not straightforward to extract. No supplementary material was found."}
{"nmadb.ID":480037,"PMID":"25441399","First.Author":"Singh","Year":"2014","Journal.Name":"Mayo Clin Proc","Title":"Comparative efficacy of biologic therapy in biologic-naïve patients with Crohn disease: a systematic review and network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Concomitant medications' are variable across the trials, increasing the risk of large missingness. Dose information was not straightforward to extact. No access to supplementary material was granted."}
{"nmadb.ID":481009,"PMID":"25485632","First.Author":"Ziakas","Year":"2014","Journal.Name":"PLoS One","Title":"Graft-Versus-Host Disease Prophylaxis after Transplantation: A Network Meta-Analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 & S2","Comment":"NA"}
{"nmadb.ID":480804,"PMID":"25486075","First.Author":"Palmer","Year":"2014","Journal.Name":"Cochrane Database Syst Rev","Title":"Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies","Comment":"NA"}
{"nmadb.ID":481323,"PMID":"26424119","First.Author":"Mills","Year":"2014","Journal.Name":"Lancet HIV","Title":"Interventions to promote adherence to antiretroviral therapy in Africa: a network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 1 (page 24)","Comment":"Participant characteristics are reported by arm. There was no information on risk of bias domains."}
{"nmadb.ID":479969,"PMID":"24412033","First.Author":"Lewis","Year":"2015","Journal.Name":"Spine J","Title":"Comparative clinical effectiveness of management strategies for sciatica: systematic review and network meta-analyses","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables B2 & B3","Comment":"NA"}
{"nmadb.ID":479629,"PMID":"24640991","First.Author":"Reinecke","Year":"2015","Journal.Name":"Br J Pharmacol","Title":"Analgesic efficacy of opioids in chronic pain: recent meta-analyses","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S4 to S5","Comment":"Risk of bias domains are not reported for the extracted studies."}
{"nmadb.ID":481174,"PMID":"24989022","First.Author":"Mantha","Year":"2015","Journal.Name":"J Thromb Thrombolysis","Title":"Indirect comparison of dabigatran, rivaroxaban, apixaban and edoxaban for the treatment of acute venous thromboembolism","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"Risk of bias domains are not found in the supplementary material or main article. Characteristics are reported per arm."}
{"nmadb.ID":480052,"PMID":"25263803","First.Author":"Singh","Year":"2015","Journal.Name":"Gastroenterology","Title":"Comparative Efficacy of Pharmacologic Interventions in Preventing Relapse of Crohn's Disease After Surgery: A Systematic Review and Network Meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1, Supplementary 1 & 2","Comment":"NA"}
{"nmadb.ID":480967,"PMID":"25375397","First.Author":"Sun","Year":"2015","Journal.Name":"Diabetes Technol Ther","Title":"Gastrointestinal Adverse Events of Glucagon-Like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 & S2","Comment":"NA"}
{"nmadb.ID":479974,"PMID":"25381743","First.Author":"Lee","Year":"2015","Journal.Name":"BJU Int","Title":"Comparative effectiveness and safety of various treatment procedures for lower pole renal calculi: a systematic review and network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"inclusion criteria' and 'treatment protocol' are textual. No further relevant information was found in the supplementary material."}
{"nmadb.ID":480074,"PMID":"25391388","First.Author":"Phan","Year":"2015","Journal.Name":"Eur J Cardiothorac Surg","Title":"Comparing energy sources for surgical ablation of atrial fibrillation: a Bayesian network meta-analysis of randomized, controlled trials","Outcome.Type":"Objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"CS type' and 'lesion set' have multiple values in some trials and each value *should* be extracted in a column as dummy variable. No supplementary material nor information on the risk of bias domains were found."}
{"nmadb.ID":479996,"PMID":"25448924","First.Author":"Hazlewood","Year":"2015","Journal.Name":"Gastroenterology","Title":"Comparative Effectiveness of Immunosuppressants and Biologics for Inducing and Maintaining Remission in Crohn's Disease: A Network Meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 (bottom manuscript) & S3","Comment":"Baseline disease severity at the time of randomization' is not straightforward to extract."}
{"nmadb.ID":481354,"PMID":"25523487","First.Author":"Haspinger","Year":"2015","Journal.Name":"Crit Rev Oncol Hematol","Title":"Is there evidence for different effects among EGFR-TKIs? Systematicreview and meta-analysis of EGFR tyrosine kinase inhibitors (TKIs)versus chemotherapy as first-line treatment for patients harboring EGFR mutations","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Table 1 & Figure 6","Comment":"NA"}
{"nmadb.ID":482231,"PMID":"25555272","First.Author":"Bulluck","Year":"2015","Journal.Name":"Int J Cardiol","Title":"Safety of short-term dual antiplatelet therapy after drug-eluting stents:An updated meta-analysis with direct and adjusted indirect comparison of randomized control trials","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Both","Source.ToC":"Table 1, Appendices 3, 6 & 7","Comment":"Appendix 4 has too many missing data for the extractable variables that is not worthy to extract. Appendix 6 has heterogeneous reporting of the characteristics for compliance: some trials report per arm and others for the whole trial."}
{"nmadb.ID":480667,"PMID":"25583895","First.Author":"Linde","Year":"2015","Journal.Name":"Ann Fam Med","Title":"Efficacy and Acceptability of Pharmacological Treatments for Depressive Disorders in Primary Care: Systematic Review and Network Meta-Analysis","Outcome.Type":"Subjective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Tables S1 & S3","Comment":"NA"}
{"nmadb.ID":481736,"PMID":"25609326","First.Author":"Nelson","Year":"2015","Journal.Name":"J Allergy Clin Immunol Pract","Title":"Network Meta-analysis Shows Commercialized Subcutaneous and Sublingual Grass Products Have Comparable Efficacy","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"Risk of bias domains are not reported in the supplementary or main article. 'Pollen season' can be categorised."}
{"nmadb.ID":476343,"PMID":"25626481","First.Author":"Edwards","Year":"2015","Journal.Name":"Health Technol Assess","Title":"Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for advanced recurrent or refractory ovarian cancer: a systematic review and economic evaluation","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendices 2 &12","Comment":"Characteristics are reported per arm."}
{"nmadb.ID":479770,"PMID":"25652947","First.Author":"Greco","Year":"2015","Journal.Name":"Br J Anaesth","Title":"A Bayesian network meta-analysis on the effect of inodilatory agents on mortality","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Both","Source.ToC":"Table 1 & only-online Table 1","Comment":"NA"}
{"nmadb.ID":481378,"PMID":"25656228","First.Author":"Alfirevic","Year":"2015","Journal.Name":"BMJ","Title":"Labour induction with prostaglandins: a systematic review and network meta-analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix 4","Comment":"Appendix 5 on doses is fully mixed, hindering a straightforward extraction. Appendix 6, Table 1b to 3b summarise the characteristics per intervention."}
{"nmadb.ID":480926,"PMID":"25677267","First.Author":"Messori","Year":"2015","Journal.Name":"Ann Hematol","Title":"First-line treatments for chronic lymphocytic leUnited Kingdomaemia: interpreting efficacy data by network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1 & Figure S2","Comment":"No clinical characteristics are reported."}
{"nmadb.ID":482416,"PMID":"25705221","First.Author":"Huai","Year":"2015","Journal.Name":"Gastroenterol Res Pract","Title":"Submucosal Injection Solution for Endoscopic Resection in Gastrointestinal Tract: A Traditional and Network Meta-Analysis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 1 & 2","Comment":"Site' and 'type' overlap weakly across the trials, rendering extraction not straightforward."}
{"nmadb.ID":479914,"PMID":"25760991","First.Author":"Loveman","Year":"2015","Journal.Name":"Health Technol Assess","Title":"The clinical effectiveness and cost-effectiveness of treatments for idiopathic pulmonary fibrosis: a systematic review and economic evaluation","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Appendix 5","Comment":"NA"}
{"nmadb.ID":482630,"PMID":"25761173","First.Author":"Dong","Year":"2015","Journal.Name":"Medicine","Title":"Treatments for Shoulder Impingement Syndrome A PRISMA Systematic Review and Network Meta-Analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Main text","Source.ToC":"Table 1 & Figure 2","Comment":"NA"}
{"nmadb.ID":480612,"PMID":"25793900","First.Author":"Kunitomi","Year":"2015","Journal.Name":"PLoS One","Title":"Effect of Common Comparators in Indirect Comparison Analysis of the Effectiveness of Different Inhaled Corticosteroids in the Treatment of Asthma","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Main text","Source.ToC":"Table 1","Comment":"No information on the risk of bias domains in the supplementary material or main article."}
{"nmadb.ID":481147,"PMID":"25817087","First.Author":"Galvan-Banqueri","Year":"2015","Journal.Name":"Farm Hosp","Title":"Indirect comparison for Anti-TNF drugs in moderate to severe ulcerative colitis","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Main text","Source.ToC":"Tables 2 & 3","Comment":"% concomitant medication' does not overlap sufficiently across the trials to allow a straightforward extraction."}
{"nmadb.ID":482519,"PMID":"25864873","First.Author":"Moja","Year":"2015","Journal.Name":"Aliment Pharmacol Ther","Title":"Systematic review with network meta-analysis: comparative efficacy and safety of budesonide and mesalazine (mesalamine) for Crohn's disease","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Table S1 & Figure S1","Comment":"Risk of bias domains and no patient characteristics: country, multicenter, sample size and duration. Disease distribution overlaps for some trials and does not provide number for some of those. Dose is part of the node and it will not be extracted."}
{"nmadb.ID":479664,"PMID":"25879115","First.Author":"Wilhelmus","Year":"2015","Journal.Name":"Cochrane Database Syst Rev","Title":"Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis herpes simplex virus epithelial keratitis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"non-pharmacological vs any","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies","Comment":"NA"}
{"nmadb.ID":482104,"PMID":"25879879","First.Author":"van Walsem","Year":"2015","Journal.Name":"Arthritis Res Ther","Title":"Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysis","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Excel 4 & 5","Comment":"Dose is part of the nodes."}
{"nmadb.ID":482576,"PMID":"25887212","First.Author":"Maxwell","Year":"2015","Journal.Name":"Cochrane Database Syst Rev","Title":"TNF-alpha inhibitors for ankylosing spondylitis (Review)","Outcome.Type":"Semi-objective","Intervention.Comparison.Type":"pharmacological vs placebo","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies & Table 7","Comment":"NA"}
{"nmadb.ID":482472,"PMID":"25887385","First.Author":"Bow","Year":"2015","Journal.Name":"BMC Infect Dis","Title":"Systematic review and mixed treatment comparison meta-analysis of randomized clinical trials of primary oral antifungal prophylaxis in allogeneic hematopoietic cell transplant recipients","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Results – Key information about each identified RCT","Comment":"No information on the risk of bias domains was found in the supplementary material or the main article."}
{"nmadb.ID":481988,"PMID":"25897764","First.Author":"Dumville","Year":"2015","Journal.Name":"Cochrane Database Syst Rev","Title":"Preoperative skin antiseptics for preventing surgical wound infections after clean surgery (Review)","Outcome.Type":"Objective","Intervention.Comparison.Type":"pharmacological vs pharmacological","Includes.ToC.where":"Supplementary file","Source.ToC":"Characteristics of included studies","Comment":"Best efforts were made to extract what could be extractable for most trials."}